Which word is synonymous with 'to cause irritation or anger'?

The term that best captures the idea of 'to cause irritation or anger' includes both "vex" and "rankle."

"Vex" specifically means to irritate or annoy someone, often in a way that provokes frustration. It conveys a sense of mental distress or trouble, making it an apt choice for expressing irritation.

"Rankle," on the other hand, suggests a deeper, more persistent source of irritation or resentment. When something rankles, it causes ongoing discomfort or anger, often indicating a wound that has not healed or a grievance that continues to bother someone.

Both words effectively communicate different nuances of causing irritation or anger, making the combined choice of both "vex" and "rankle" the correct answer.