Which adjective best describes someone who is skillful with their hands or mind?

The adjective "adroit" is the best choice to describe someone who is skillful with their hands or mind. This word conveys a sense of proficiency and dexterity, whether in a physical task or a mental challenge. For instance, an adroit craftsman demonstrates remarkable skill in working with tools, while an adroit thinker shows sharpness and cleverness in problem-solving or intellectual pursuits.

This choice aligns perfectly with the intention of the question, which seeks to highlight a person's skill and capability, further suggesting a natural talent or learned expertise. The other options, such as "clumsy," "incompetent," and "indifferent," imply a lack of skill or care, which directly contrasts the positive representation that "adroit" provides. Thus, "adroit" effectively encapsulates the qualities of skillfulness and adeptness, making it the most appropriate answer.